From medical point of view, “Diarrhea” is an alteration in a normal bowel movement characterized by an increase in the water content, volume, or frequency of stools. Acute diarrhea of infec­tious etiology, often referred to as gastroenteri­tis and is typically associated with clinical signs and symptoms including: nausea, vomiting, abdomi­nal pain and cramps, bloating, flatulence, fever, passage of bloody stools, tenesmus, and fecal ur­gency. Infectious diarrheal diseases are the second leading cause of morbidity and mortality worldwide. It is the diarrhea we have also found out, during a large 3 yeas study 2017-2020 in Transylvania – Romania. 3577 number of cases were transmitted during this time, to our Public Health Center, by 12 district Sanitary Polices. These were mostly diagnosed by the territorial family doctors and more than 50%, have need hospitalization, for several days because of the mentioned disease disorders. The detected infectious etiology, were determined in authorized laboratories in which it was identified: Shigella, Salmonella, Campylobacter, and Yersinia, Rotavirus, Giardia. Most number of cases appeared in children, followed by elderly or adult people, as quantified number of determination. In light of these data, acute diarrheal illness had to be considered a major public health issue against which control efforts are needed. Public health surveillance and response in the field of infectious acute diarrhea include obligatory strategies of infection control.

Since the beginning of the twenty-one century, carbon based nanomaterial (CNTs) has been introduced in (pharmacy and medicine) in therapeutic for system of drug delivery. NTs have proved able to transport a wide range of molecules across membranes and into living cells; therefore, they have attracted great interest in biomedical applications such as advanced imaging, tissue regeneration, and drug or gene deliver. As it is known, carbon nanotubes exhibit various unique intrinsic chemical and physical properties and it has been intensive explored, in the last few years, for applications in biology and biomedicine.

Aim: This retrospective analysis of the GFR values of the individual moieties obtained by using a novel software with modified GATE’S formula in the in house software created at SSSIHL, compared and evaluated with the value derived by the combined GFR value of the single kidney GFR as obtained from the Icon software loaded in the gamma camera. Materials and Method: This retrospective study of 10patients diagnosed with unilateral double moiety and 5 patients with bilateral duplication was undertaken to validate the modified GATE’S formula in house software created at SSSIHL. This group had 12 males in the age range of 03-66 years with the mean age of 26.5 ± 2 years and 3 females in the age range of 29 – 31 years with mean age of 31 ± 2 years. Renal scans were done using Siemens dual head gamma camera (E.CAM). The radiopharmaceutical 99mTc-DTPA 5 mCi was injected as a bolus intravenously for the adult patients and 3 mCi was injected for the children. The images were obtained and processed by using GFR/Renal differential processing protocol in icon software. Later the raw data of the scan study transferred to the workstation loaded with the in house software created at SSSIHL with modified GATE’S formula created by us. The individual moiety GFR values were calculated using the software with modified Gate’s formula developed in MATLAB GUI algorithm and tabulated. Then the combined value of individual moiety GFR values compared with that of the individual whole kidney GFR value obtained by the Icon software protocol. Result: The T test evaluation done in the online statistical calculator of Maths Portal org revealed that the mean values of the two groups showed no significant difference at p < 0.05. The calculated t value is smaller than the critical value (0.0217 < 2.024), so the means are not significantly different. Pearson Correlation performed between the above two samples using statistical online calculators also showed the correlation coefficient of r = 0.9247 and a mean difference of 0.09 indicating that the high correlation between them. The observed significance p value < 0.0001 at t value of 10.27, showed no significant difference detected between the two samples. Conclusion: It can be concluded that the in house software created at SSSIHL with modified GATE’S formula method of GFR calculating software showed identical values with that of the GFR calculated with the original Gate’s formula. This was found to be useful in calculating the GFR of individual moieties separately in the cases of Double moieties in both Unilateral and Bilateral involvement effectively. The utility and usefulness of the separate estimation of individual moieties GFR needed for Nephron Sparing Surgery.

Coronavirus is here to stay In January, Nature asked more than 100 immunologists, infectious-disease researchers and virologists working on SARS-CoV-2 whether it could be eradicated. Almost 90% of respondents think that the coronavirus will become endemic — meaning that it will continue to circulate in pockets of the global population for years to come. But failure to eradicate the virus does not mean that death, illness and social isolation will continue on the scales seen so far. The future will depend heavily on the type of immunity people acquire and how the virus evolves. A different opinion: A minority report of one: Coronavirus may not go completely away but will be reduced in size and severity and its mortality greatly reduced: An optimistic hopeful minority report, Covid-19 pandemic war lockdown will end triumphantly before the start of May.